{"@context":"http://iiif.io/api/presentation/3/context.json","id":"https://ualberta.aviaryplatform.com/iiif/c53dz04t9w/manifest","type":"Manifest","label":{"en":["S1E3: Come Fruit Fly With Me"]},"logo":"https://d9jk7wjtjpu5g.cloudfront.net/organizations/logo_images/000/000/128/original/UA_Logo_WHT_RGB_%281%29.png?1725471982","metadata":[{"label":{"en":["Agent"]},"value":{"en":["Tetro, Jason (Creator)","Shahid, Nayiar (Host)","Hughes. Sarah (Interviewee)","Tetro, Jason (Producer)"]}},{"label":{"en":["Date"]},"value":{"en":["2026-05-19 (Issued)"]}},{"label":{"en":["Language"]},"value":{"en":["English"]}},{"label":{"en":["Description"]},"value":{"en":["\u003cp\u003eMost people see the fruit fly as a kitchen nuisance or an agricultural menace, but to cancer researchers, Drosophila is a giant in the field. In this episode of Science at the Fifty-Third Degree, host Dr. Nayiar Shahid talks with Dr. Sarah Hughes, a Medical Genetics professor at the University of Alberta.\u003c/p\u003e\r\n\u003cp\u003eDr. Hughes explains why this tiny insect is a foundational tool for human oncology, sharing roughly 75% of human cancer genes. The conversation dives deep into the SNR1 gene (known as SMARCB1 in humans), a critical regulator of chromatin remodeling. When this regulation fails, neural stem cells become \"confused,\" leading to aggressive pediatric brain tumors like Atypical Rhabdoid Tumors (ATRT).\u003c/p\u003e\r\n\u003cp\u003eThis episode covers:\u003c/p\u003e\r\n\u003cp\u003e● Why fruit flies are powerful models for human organ systems.\u003c/p\u003e\r\n\u003cp\u003e● The role of SNR1/SMARCB1 in stopping proliferation and guiding cell differentiation.\u003c/p\u003e\r\n\u003cp\u003e● How \"stem-cell-like\" cells in the wrong place lead to tumor overgrowth.\u003c/p\u003e\r\n\u003cp\u003e● The future of RNA-based therapies to regulate protein production.\u003c/p\u003e\r\n\u003cp\u003e● The importance of lab culture and mentorship in driving scientific discovery.\u003c/p\u003e\r\n\u003cp\u003e \u003c/p\u003e (Summary)","\u003cp\u003eScience at the Fifty-Third Degree is produced at the University of Alberta and available on the Aviary platform and wherever you listen to podcasts. Questions? \u003ca title=\"basicsci@ualberta.ca\" href=\"mailto:basicsci@ualberta.ca\"\u003ebasicsci@ualberta.ca\u003c/a\u003e\u003c/p\u003e (General)"]}},{"label":{"en":["Subject"]},"value":{"en":["Drosophila Research (Topical)","Pediatric Oncology (Topical)","Genetics (Topical)","Molecular Biology (Topical)","Chromatin Remodeling (Topical)","Stem Cell Fate (Topical)","Science Mentorship (Topical)","University of Alberta (Topical)"]}},{"label":{"en":["Rights Statement"]},"value":{"en":["\u003cp\u003e\u003ca title=\"Creative Commons Attribution-NonCommercial 4.0 International\" href=\"https://creativecommons.org/licenses/by-nc/4.0/\"\u003eCreative Commons Attribution-NonCommercial 4.0 International\u003c/a\u003e\u003c/p\u003e"]}}],"summary":{"en":["\u003cp\u003eMost people see the fruit fly as a kitchen nuisance or an agricultural menace, but to cancer researchers, Drosophila is a giant in the field. In this episode of Science at the Fifty-Third Degree, host Dr. Nayiar Shahid talks with Dr. Sarah Hughes, a Medical Genetics professor at the University of Alberta.\u003c/p\u003e\r\n\u003cp\u003eDr. Hughes explains why this tiny insect is a foundational tool for human oncology, sharing roughly 75% of human cancer genes. The conversation dives deep into the SNR1 gene (known as SMARCB1 in humans), a critical regulator of chromatin remodeling. When this regulation fails, neural stem cells become \"confused,\" leading to aggressive pediatric brain tumors like Atypical Rhabdoid Tumors (ATRT).\u003c/p\u003e\r\n\u003cp\u003eThis episode covers:\u003c/p\u003e\r\n\u003cp\u003e● Why fruit flies are powerful models for human organ systems.\u003c/p\u003e\r\n\u003cp\u003e● The role of SNR1/SMARCB1 in stopping proliferation and guiding cell differentiation.\u003c/p\u003e\r\n\u003cp\u003e● How \"stem-cell-like\" cells in the wrong place lead to tumor overgrowth.\u003c/p\u003e\r\n\u003cp\u003e● The future of RNA-based therapies to regulate protein production.\u003c/p\u003e\r\n\u003cp\u003e● The importance of lab culture and mentorship in driving scientific discovery.\u003c/p\u003e\r\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e","\u003cp\u003eScience at the Fifty-Third Degree is produced at the University of Alberta and available on the Aviary platform and wherever you listen to podcasts. Questions? \u003ca title=\"basicsci@ualberta.ca\" href=\"mailto:basicsci@ualberta.ca\" target=\"_blank\" rel=\"noopener\"\u003ebasicsci@ualberta.ca\u003c/a\u003e\u003c/p\u003e"]},"requiredStatement":{"label":{"en":["Attribution"]},"value":{"en":["\u003cp\u003e\u003ca title=\"Creative Commons Attribution-NonCommercial 4.0 International\" href=\"https://creativecommons.org/licenses/by-nc/4.0/\" target=\"_blank\" rel=\"noopener\"\u003eCreative Commons Attribution-NonCommercial 4.0 International\u003c/a\u003e\u003c/p\u003e"]}},"provider":[{"id":"https://ualberta.aviaryplatform.com/aboutus","type":"Agent","label":{"en":["University of Alberta Library"]},"homepage":[{"id":"https://ualberta.aviaryplatform.com/","type":"Text","label":{"en":["University of Alberta Library"]},"format":"text/html"}],"logo":[{"id":"https://d9jk7wjtjpu5g.cloudfront.net/organizations/logo_images/000/000/128/original/UA_Logo_WHT_RGB_%281%29.png?1725471982","type":"Image"}]}],"thumbnail":[{"id":"https://d9jk7wjtjpu5g.cloudfront.net/collections/default_thumbs/000/003/684/small/Science-at-the-Fifty-Third-Degree-16x9.png?1778098300","type":"Image","format":"image/png"}],"items":[{"id":"https://ualberta.aviaryplatform.com/collections/3684/collection_resources/170066/file/308946","type":"Canvas","label":{"en":["Media File 1 of 1 - Come-Fruit-Fly-With-Me.mp3"]},"duration":870.936,"width":640,"height":40,"thumbnail":[{"id":"https://d9jk7wjtjpu5g.cloudfront.net/collections/default_thumbs/000/003/684/small/Science-at-the-Fifty-Third-Degree-16x9.png?1778098300","type":"Image","format":"image/png"}],"items":[{"id":"https://ualberta.aviaryplatform.com/collections/3684/collection_resources/170066/file/308946/content/1","type":"AnnotationPage","items":[{"id":"https://ualberta.aviaryplatform.com/collections/3684/collection_resources/170066/file/308946/content/1/annotation/1","type":"Annotation","motivation":"painting","body":{"id":"https://aviary-p-ualberta.s3.wasabisys.com/collection_resource_files/resource_files/000/308/946/original/Come-Fruit-Fly-With-Me.mp3?1778192476","type":"Audio","format":"audio/mpeg","duration":870.936,"width":640,"height":40},"target":"https://ualberta.aviaryplatform.com/collections/3684/collection_resources/170066/file/308946","metadata":[]}]}],"annotations":[]}]}