{"@context":"http://iiif.io/api/presentation/3/context.json","id":"https://ualberta.aviaryplatform.com/iiif/6t0gt5hc7s/manifest","type":"Manifest","label":{"en":["S1E8: If He Could Turn Back Time"]},"logo":"https://d9jk7wjtjpu5g.cloudfront.net/organizations/logo_images/000/000/128/original/UA_Logo_WHT_RGB_%281%29.png?1725471982","metadata":[{"label":{"en":["Agent"]},"value":{"en":["Tetro, Jason (Creator)","Shahid, Nayiar (Host)","Gupta, Sandeep (Interviewee)","Tetro, Jason (Producer)"]}},{"label":{"en":["Date"]},"value":{"en":["2026-06-23 (Issued)"]}},{"label":{"en":["Language"]},"value":{"en":["English"]}},{"label":{"en":["Description"]},"value":{"en":["\u003cp\u003eImagine taking a page from a book, wiping it completely blank, and writing an entirely different story on it. In the world of cell biology, this is called cellular reprogramming. In this episode of Science at the Fifty-Third Degree, host Dr. Nayiar Shahid steps into a cellular time machine with Dr. Sandeep Gupta from the Department of Cell Biology at the University of Alberta to look at how scientists are turning back the clock on human cells.    Using Induced Pluripotent Stem Cell (iPSC) technology, Dr. Gupta’s lab takes simple skin or blood cells from patients and coaxes them to forget their adult identity, returning them to an embryonic blank slate. From there, they can grow patient-specific brain and spinal cord neurons in a dish. This groundbreaking approach allows researchers to study the fundamental biology of Autism Spectrum Disorder (ASD) and explore sensory dysfunction directly at its source.\u003c/p\u003e\r\n\u003cp\u003eThis episode covers:\u003c/p\u003e\r\n\u003cp\u003e● The high-tech wizardry behind cellular reprogramming and rewiring transcriptomic structures.\u003c/p\u003e\r\n\u003cp\u003e● How the discovery of the Yamanaka factors (OSKM: OCT4, SOX2, KLF4, c-MYC) eliminated the need for human embryos in stem cell research.\u003c/p\u003e\r\n\u003cp\u003e● Mapping the massive diversity of autism by looking at mutations across nearly 1,000 risk genes.\u003c/p\u003e\r\n\u003cp\u003e● Dr. Gupta's exciting, brand-new data revealing the critical role of the spinal cord as a sensory gating mechanism in autism.\u003c/p\u003e\r\n\u003cp\u003e● How \"brain in a dish\" models have moved from science fiction to standardized drug-discovery platforms for precision medicine.\u003c/p\u003e (Summary)","\u003cp\u003eNote: Science at the Fifty-Third Degree is produced by the University of Alberta Basic Science Administrative Team and is available on the Aviary platform and wherever you listen to podcasts. Questions or feedback? Reach us at basicsci@ualberta.ca.\u003c/p\u003e (General)"]}},{"label":{"en":["Subject"]},"value":{"en":["Cell Biology (Topical)","Stem Cell Research (Topical)","Induced Pluripotent Stem Cells (iPSCs) (Topical)","Behavioral Neuroscience (Topical)","Autism Spectrum Disorder (Topical)","Sensory Gating Mechanisms (Topical)","Translational Medicine (Topical)"]}},{"label":{"en":["Rights Statement"]},"value":{"en":["\u003cp\u003e\u003ca href=\"https://creativecommons.org/licenses/by-nc/4.0/\"\u003eCreative Commons Attribution-NonCommercial 4.0 International\u003c/a\u003e\u003c/p\u003e"]}}],"summary":{"en":["\u003cp\u003eImagine taking a page from a book, wiping it completely blank, and writing an entirely different story on it. In the world of cell biology, this is called cellular reprogramming. In this episode of Science at the Fifty-Third Degree, host Dr. Nayiar Shahid steps into a cellular time machine with Dr. Sandeep Gupta from the Department of Cell Biology at the University of Alberta to look at how scientists are turning back the clock on human cells. \u0026nbsp; \u0026nbsp;Using Induced Pluripotent Stem Cell (iPSC) technology, Dr. Gupta\u0026rsquo;s lab takes simple skin or blood cells from patients and coaxes them to forget their adult identity, returning them to an embryonic blank slate. From there, they can grow patient-specific brain and spinal cord neurons in a dish. This groundbreaking approach allows researchers to study the fundamental biology of Autism Spectrum Disorder (ASD) and explore sensory dysfunction directly at its source.\u003c/p\u003e\r\n\u003cp\u003eThis episode covers:\u003c/p\u003e\r\n\u003cp\u003e● The high-tech wizardry behind cellular reprogramming and rewiring transcriptomic structures.\u003c/p\u003e\r\n\u003cp\u003e● How the discovery of the Yamanaka factors (OSKM: OCT4, SOX2, KLF4, c-MYC) eliminated the need for human embryos in stem cell research.\u003c/p\u003e\r\n\u003cp\u003e● Mapping the massive diversity of autism by looking at mutations across nearly 1,000 risk genes.\u003c/p\u003e\r\n\u003cp\u003e● Dr. Gupta's exciting, brand-new data revealing the critical role of the spinal cord as a sensory gating mechanism in autism.\u003c/p\u003e\r\n\u003cp\u003e● How \"brain in a dish\" models have moved from science fiction to standardized drug-discovery platforms for precision medicine.\u003c/p\u003e","\u003cp\u003eNote: Science at the Fifty-Third Degree is produced by the University of Alberta Basic Science Administrative Team and is available on the Aviary platform and wherever you listen to podcasts. Questions or feedback? Reach us at basicsci@ualberta.ca.\u003c/p\u003e"]},"requiredStatement":{"label":{"en":["Attribution"]},"value":{"en":["\u003cp\u003e\u003ca href=\"https://creativecommons.org/licenses/by-nc/4.0/\"\u003eCreative Commons Attribution-NonCommercial 4.0 International\u003c/a\u003e\u003c/p\u003e"]}},"provider":[{"id":"https://ualberta.aviaryplatform.com/aboutus","type":"Agent","label":{"en":["University of Alberta Library"]},"homepage":[{"id":"https://ualberta.aviaryplatform.com/","type":"Text","label":{"en":["University of Alberta Library"]},"format":"text/html"}],"logo":[{"id":"https://d9jk7wjtjpu5g.cloudfront.net/organizations/logo_images/000/000/128/original/UA_Logo_WHT_RGB_%281%29.png?1725471982","type":"Image"}]}],"thumbnail":[{"id":"https://d9jk7wjtjpu5g.cloudfront.net/collections/default_thumbs/000/003/684/small/Science-at-the-Fifty-Third-Degree-16x9.png?1778098300","type":"Image","format":"image/png"}],"items":[{"id":"https://ualberta.aviaryplatform.com/collections/3684/collection_resources/173027/file/312007","type":"Canvas","label":{"en":["Media File 1 of 1 - If-He-Could-Turn-Back-Time.wav"]},"duration":693.1551,"width":640,"height":40,"thumbnail":[{"id":"https://d9jk7wjtjpu5g.cloudfront.net/collections/default_thumbs/000/003/684/small/Science-at-the-Fifty-Third-Degree-16x9.png?1778098300","type":"Image","format":"image/png"}],"items":[{"id":"https://ualberta.aviaryplatform.com/collections/3684/collection_resources/173027/file/312007/content/1","type":"AnnotationPage","items":[{"id":"https://ualberta.aviaryplatform.com/collections/3684/collection_resources/173027/file/312007/content/1/annotation/1","type":"Annotation","motivation":"painting","body":{"id":"https://aviary-p-ualberta.s3.wasabisys.com/collection_resource_files/resource_files/000/312/007/original/If-He-Could-Turn-Back-Time.wav?1781292425","type":"Audio","format":"audio/wav","duration":693.1551,"width":640,"height":40},"target":"https://ualberta.aviaryplatform.com/collections/3684/collection_resources/173027/file/312007","metadata":[]}]}],"annotations":[]}]}