{"@context":"http://iiif.io/api/presentation/3/context.json","id":"https://ualberta.aviaryplatform.com/iiif/0g3gx46m4b/manifest","type":"Manifest","label":{"en":["S1E1: How She Mends A Broken Heart"]},"logo":"https://d9jk7wjtjpu5g.cloudfront.net/organizations/logo_images/000/000/128/original/UA_Logo_WHT_RGB_%281%29.png?1725471982","metadata":[{"label":{"en":["Agent"]},"value":{"en":["Tetro, Jason (Creator)","Shahid, Nayiar (Host)","Kassiri, Zamaneh (Interviewee)","Tetro, Jason (Producer)"]}},{"label":{"en":["Type"]},"value":{"en":["Podcast"]}},{"label":{"en":["Date"]},"value":{"en":["2026-05-05 (issued)"]}},{"label":{"en":["Language"]},"value":{"en":["English"]}},{"label":{"en":["Description"]},"value":{"en":["\u003cp\u003eYour heart beats more than 100,000 times a day without you ever asking it to. But what happens when something interrupts that rhythm — and more importantly, what happens after?\u003cbr\u003e\u003cbr\u003e\u003c/p\u003e\r\n\u003cp\u003eIn this pilot episode of Science at the Fifty-Third Degree, host Dr. Nayiar Shahid sits down with Dr. Zam Kassiri, a professor at the University of Alberta, to explore the fascinating and surprisingly delicate science of cardiac repair. After a heart attack, the heart doesn't just sit still — it begins a complex process of remodeling itself, reshaping its own structure to survive. But that same repair process, if it goes too far or lasts too long, can quietly become the source of long-term damage.\u003cbr\u003e\u003cbr\u003e\u003c/p\u003e\r\n\u003cp\u003eDr. Kassiri's research focuses on the molecular signals — including a family of proteins called ADAMs, and particularly ADAM17 — that guide whether the heart heals properly or continues to decline. Using cutting-edge tools like single-cell sequencing, her lab is mapping the conversations happening between individual cells in an injured heart, one cell at a time.\u003c/p\u003e\r\n\u003cp\u003eThis episode covers:\u003c/p\u003e\r\n\r\nWhat's actually happening inside the body during a heart attack\r\nThe process of cardiac remodeling and why timing is everything\r\nHow the same molecules that protect the heart early on can become harmful later\r\nWhat single-cell sequencing is revealing about heart disease at the microscopic level\r\nWhat it feels like to do science that could one day change — or extend — someone's life\r\n (Summary)","\u003cp\u003eNote: Science at the Fifty-Third Degree is produced by the University of Alberta Basic Science Administrative Team and is available on the Aviary platform and wherever you listen to podcasts. Questions or feedback? Reach us at \u003ca title=\"basicsci@ualberta.ca\" href=\"mailto:basicsci@ualberta.ca\"\u003ebasicsci@ualberta.ca\u003c/a\u003e.\u003c/p\u003e (general)"]}},{"label":{"en":["Subject"]},"value":{"en":["Heart attack (Topical)","Cardiac repair (Topical)","Cardiovascular research (Topical)","Cardiac remodelling (Topical)","ADAM17 (Topical)","Heart disease (Topical)","University of Alberta (Topical)","Science Podcast (Topical)","Medical Research (Topical)","Cardiology (Topical)","Single-cell sequencing (Topical)","Heart health (Topical)","Science Communication (Topical)","Edmonton, Alberta, Canada (Geographic)"]}},{"label":{"en":["Rights Statement"]},"value":{"en":["\u003cp\u003e\u003ca title=\"Creative Commons Attribution-NonCommercial 4.0 International\" href=\"https://creativecommons.org/licenses/by-nc/4.0/\"\u003eCreative Commons Attribution-NonCommercial 4.0 International\u003c/a\u003e\u003c/p\u003e"]}}],"summary":{"en":["\u003cp\u003eYour heart beats more than 100,000 times a day without you ever asking it to. But what happens when something interrupts that rhythm \u0026mdash; and more importantly, what happens after?\u003cbr /\u003e\u003cbr /\u003e\u003c/p\u003e\r\n\u003cp\u003eIn this pilot episode of Science at the Fifty-Third Degree, host Dr. Nayiar Shahid sits down with Dr. Zam Kassiri, a professor at the University of Alberta, to explore the fascinating and surprisingly delicate science of cardiac repair. After a heart attack, the heart doesn't just sit still \u0026mdash; it begins a complex process of remodeling itself, reshaping its own structure to survive. But that same repair process, if it goes too far or lasts too long, can quietly become the source of long-term damage.\u003cbr /\u003e\u003cbr /\u003e\u003c/p\u003e\r\n\u003cp\u003eDr. Kassiri's research focuses on the molecular signals \u0026mdash; including a family of proteins called ADAMs, and particularly ADAM17 \u0026mdash; that guide whether the heart heals properly or continues to decline. Using cutting-edge tools like single-cell sequencing, her lab is mapping the conversations happening between individual cells in an injured heart, one cell at a time.\u003c/p\u003e\r\n\u003cp\u003eThis episode covers:\u003c/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003eWhat's actually happening inside the body during a heart attack\u003c/li\u003e\r\n\u003cli\u003eThe process of cardiac remodeling and why timing is everything\u003c/li\u003e\r\n\u003cli\u003eHow the same molecules that protect the heart early on can become harmful later\u003c/li\u003e\r\n\u003cli\u003eWhat single-cell sequencing is revealing about heart disease at the microscopic level\u003c/li\u003e\r\n\u003cli\u003eWhat it feels like to do science that could one day change \u0026mdash; or extend \u0026mdash; someone's life\u003c/li\u003e\r\n\u003c/ul\u003e","\u003cp\u003eNote: Science at the Fifty-Third Degree is produced by the University of Alberta Basic Science Administrative Team and is available on the Aviary platform and wherever you listen to podcasts. Questions or feedback? Reach us at \u003ca title=\"basicsci@ualberta.ca\" href=\"mailto:basicsci@ualberta.ca\" target=\"_blank\" rel=\"noopener\"\u003ebasicsci@ualberta.ca\u003c/a\u003e.\u003c/p\u003e"]},"requiredStatement":{"label":{"en":["Attribution"]},"value":{"en":["\u003cp\u003e\u003ca title=\"Creative Commons Attribution-NonCommercial 4.0 International\" href=\"https://creativecommons.org/licenses/by-nc/4.0/\" target=\"_blank\" rel=\"noopener\"\u003eCreative Commons Attribution-NonCommercial 4.0 International\u003c/a\u003e\u003c/p\u003e"]}},"provider":[{"id":"https://ualberta.aviaryplatform.com/aboutus","type":"Agent","label":{"en":["University of Alberta Library"]},"homepage":[{"id":"https://ualberta.aviaryplatform.com/","type":"Text","label":{"en":["University of Alberta Library"]},"format":"text/html"}],"logo":[{"id":"https://d9jk7wjtjpu5g.cloudfront.net/organizations/logo_images/000/000/128/original/UA_Logo_WHT_RGB_%281%29.png?1725471982","type":"Image"}]}],"thumbnail":[{"id":"https://d9jk7wjtjpu5g.cloudfront.net/collections/default_thumbs/000/003/684/small/Science-at-the-Fifty-Third-Degree-16x9.png?1778098300","type":"Image","format":"image/png"}],"items":[{"id":"https://ualberta.aviaryplatform.com/collections/3684/collection_resources/170054/file/308930","type":"Canvas","label":{"en":["Media File 1 of 1 - How-She-Mends-A-Broken-Heart.wav"]},"duration":1126.0704,"width":640,"height":40,"thumbnail":[{"id":"https://d9jk7wjtjpu5g.cloudfront.net/collections/default_thumbs/000/003/684/small/Science-at-the-Fifty-Third-Degree-16x9.png?1778098300","type":"Image","format":"image/png"}],"items":[{"id":"https://ualberta.aviaryplatform.com/collections/3684/collection_resources/170054/file/308930/content/1","type":"AnnotationPage","items":[{"id":"https://ualberta.aviaryplatform.com/collections/3684/collection_resources/170054/file/308930/content/1/annotation/1","type":"Annotation","motivation":"painting","body":{"id":"https://aviary-p-ualberta.s3.wasabisys.com/collection_resource_files/resource_files/000/308/930/original/How-She-Mends-A-Broken-Heart.wav?1778097625","type":"Audio","format":"audio/wav","duration":1126.0704,"width":640,"height":40},"target":"https://ualberta.aviaryplatform.com/collections/3684/collection_resources/170054/file/308930","metadata":[]}]}],"annotations":[]}]}